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Tenderloin edge meets "Let's put on a show!" pluck in Left Coast Theatre's clothes-shedding, zinger-flinging production of "The Most Fabulous Story Ever Told." An ideal prophylactic against the coming holiday season, Paul Rudnick's Bible-thumping comedy (both Testaments are pretty much beaten to a pulp) was originally produced over 20 years ago, but still packs comedic punch thanks to its timeless targets of organized religion and homophobic bigotry.

In the first of two only-loosely related acts, we meet Adam and Steve, played with goofy, cartoonish, briefly buck-naked glee by Max Seijas and Mikey Conner. You're not allowed to touch their junk, but in the wee, seedy Eden of Eddy Street's Exit Theater, you can practically catch a whiff of perineal perspiration. There's no rib-removal but plenty of rib-tickling as they're joined by their lesbian counterparts: Jane (Antonia Blumberg), a crunchy granola New Ager, and Mabel (Jessica Lim), a bossy-in-overalls Lea DeLaria type. A newfangled, dick-dangled spin on Bible stories ensues, highlighted by a beast of a circuit party aboard Noah's Ark, during which Steve is propositioned by a prominently protuberant rhinoceros played by Byron Guo, precipitating one of several relationship-straining crises among our leading couples.

The evening's second act finds a religiously mixed gang of queer New Yorkers (Christians, Jews, atheists and a Mormon) celebrating a consumerist Christmas along with queer marriage and parenting. Jokes-a-million are thrown at the walls, and most stick. Amidst the barrage of one-liners, playwright Rudnick ("Jeffrey") suggests that we've come a long way, baby (Jesus), but still have plenty of room to grow. Rudnick is never able to keep a straight face for long, and whenever a semi-serious bit of dialogue pops up, it's quickly crowded out by another punchline or auxiliary characters, like a wheelchair-bound lesbian rabbi with a cable TV show and a tinge of Marianne Williamson (Kim Saunders, chewing her way through Christian Heppinstall's sparse but effective scenery), or an off-duty go-go boy (Guo again, adorable again).

The simple production — Dr. Seuss-evocative cardboard trees, Crayola-colored jockstraps, generic holiday décor — feels altogether appropriate for the sketch-comedy feel of Rudnick's best material here, which director Neil Higgins highlights rather than the show's fleeting half-moments of half-baked philosophy.

Ribald, loose-jointed and playful, this production is a sort of happily subversive queer community theater that's all-too-rare in San Francisco these day. Its handmade feel and upbeat spirit deserve a warm embrace from audiences. It feels genuinely mirthful and uncommercial.

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The Most Fabulous Story Ever Told, Thurs.-Sat. through Dec. 14. Exit Theater, 156 Eddy St., SF. Tickets ($29.99): (415) 673-3847, www.lctcsf.org

Jim Gladstone brings the curiousity of his inner child (and the wisdom of a well-ripened adult) to projects in brand strategy, journalism, content marketing and copywriting. He’s prone to say “Yes!” to virtually any invitation to have an exploratory conversation over coffee or drinks. Read his full bio.